Details

Autor(en) / Beteiligte

• Thompson, Leslie Michels
• Aiken, Charity T
• Kaltenbach, Linda S
• Agrawal, Namita
• Illes, Katalin
• Khoshnan, Ali
• Martinez-Vincente, Marta
• Arrasate, Montserrat
• O'Rourke, Jacqueline Gire
• Khashwji, Hasan
• Lukacsovich, Tamas
• Zhu, Ya-Zhen
• Lau, Alice L
• Massey, Ashish
• Hayden, Michael R
• Zeitlin, Scott O
• Finkbeiner, Steven
• Green, Kim N
• LaFerla, Frank M
• Bates, Gillian
• Huang, Lan
• Patterson, Paul H
• Lo, Donald C
• Cuervo, Ana Maria
• Marsh, J. Lawrence
• Steffan, Joan S

Titel

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Ist Teil von

• The Journal of cell biology, 2009-12, Vol.187 (7), p.1083-1099

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2009

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatments designed to activate mutant Htt clearance pathways. We find that Htt is phosphorylated by the inflammatory kinase IKK, enhancing its normal clearance by the proteasome and lysosome. Phosphorylation of Htt regulates additional post-translational modifications, including Htt ubiquitination, SUMOylation, and acetylation, and increases Htt nuclear localization, cleavage, and clearance mediated by lysosomal-associated membrane protein 2A and Hsc70. We propose that IKK activates mutant Htt clearance until an age-related loss of proteasome/lysosome function promotes accumulation of toxic post-translationally modified mutant Htt. Thus, IKK activation may modulate mutant Htt neurotoxicity depending on the cell's ability to degrade the modified species.