Details

Autor(en) / Beteiligte

• Sabio, Guadalupe
• Cavanagh-Kyros, Julie
• Ko, Hwi Jin
• Jung, Dae Young
• Gray, Susan
• Jun, John Y.
• Barrett, Tamera
• Mora, Alfonso
• Kim, Jason K.
• Davis, Roger J.

Titel

Prevention of Steatosis by Hepatic JNK1

Ist Teil von

• Cell metabolism, 2009-12, Vol.10 (6), p.491-498

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Nonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun NH2-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful for treatment of this disease. Indeed, mice with defects in JNK1 expression in adipose tissue are protected against hepatic steatosis. Here we report that mice with specific ablation of Jnk1 in hepatocytes exhibit glucose intolerance, insulin resistance, and hepatic steatosis. JNK1 therefore serves opposing actions in liver and adipose tissue to both promote and prevent hepatic steatosis. This finding has potential implications for the design of JNK1-selective drugs for the treatment of metabolic syndrome.