Details

Autor(en) / Beteiligte

• Rouse, Dwight J
• Hirtz, Deborah G
• Thom, Elizabeth
• Varner, Michael W
• Spong, Catherine Y
• Mercer, Brian M
• Iams, Jay D
• Wapner, Ronald J
• Sorokin, Yoram
• Alexander, James M
• Harper, Margaret
• Thorp, John M
• Ramin, Susan M
• Malone, Fergal D
• Carpenter, Marshall
• Miodovnik, Menachem
• Moawad, Atef
• O'Sullivan, Mary J
• Peaceman, Alan M
• Hankins, Gary D.V
• Langer, Oded
• Caritis, Steve N
• Roberts, James M

Titel

A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy

Ist Teil von

• The New England journal of medicine, 2008-08, Vol.359 (9), p.895-905

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• In this multicenter, placebo-controlled, randomized trial of intravenous magnesium sulfate in women at imminent risk for delivery between 24 and 31 weeks of gestation, magnesium sulfate did not significantly reduce the primary composite outcome of moderate or severe cerebral palsy or death. However, it did result in a reduced rate of cerebral palsy among survivors (a prespecified secondary outcome), which may suggest the possibility of benefit. In women at imminent risk for delivery between 24 and 31 weeks of gestation, magnesium sulfate did not significantly reduce the primary composite outcome of moderate or severe cerebral palsy or death. However, it did result in a reduced rate of cerebral palsy among survivors. Cerebral palsy is characterized by abnormal control of movement and posture that results in limitation of activity. It is caused by nonprogressive damage or dysfunction of the developing fetal or infant brain 1 and is a leading cause of chronic childhood disability, with profound medical, emotional, and economic consequences. 2 Preterm birth is a risk factor for cerebral palsy, and the magnitude of the risk is inversely correlated with gestational age at birth. 3 During the past 20 to 30 years, the survival of infants born markedly preterm has improved dramatically, and whereas some data suggest that the rate of cerebral palsy among . . .