Neuroreport, 2008-07, Vol.19 (11), p.1151-1154
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Glutamine uptake contributes to central sensitization in the medullary dorsal horn
- Ist Teil von
- Neuroreport, 2008-07, Vol.19 (11), p.1151-1154
- Ort / Verlag
- Hagerstown, MD: Lippincott Williams & Wilkins, Inc
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Mustard oil application to tooth pulp produces central sensitization in rat medullary dorsal horn (MDH) nociceptive neurons, which has been implicated in persistent pain mechanisms. We found that superfusion onto MDH of methylaminoisobutyric acid, a competitive inhibitor of the neuronal system A transporter for presynaptic uptake of glutamine (a glutamate precursor released from astroglia), significantly depressed development of mustard oil-induced central sensitization in rat MDH nociceptive neurons. This finding indicates that the system A transporter is required for the expression of central sensitization and confirms the important roles of astroglia, glutamine and presynaptic modulation of glutamate release in the development of central sensitization.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0959-4965eISSN: 1473-558XDOI: 10.1097/WNR.0b013e3283086781Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2801407
- Format
- –
- Schlagworte
- Amino Acid Transport System A - antagonists & inhibitors, Animals, beta-Alanine - analogs & derivatives, beta-Alanine - pharmacology, Biological and medical sciences, Dental Pulp - innervation, Drug Interactions, Fundamental and applied biological sciences. Psychology, Glutamine - metabolism, Glutamine - pharmacokinetics, Male, Medulla Oblongata - cytology, Medulla Oblongata - metabolism, Mustard Plant, Nociceptors - drug effects, Nociceptors - physiology, Pain - physiopathology, Pain - prevention & control, Pain Threshold - drug effects, Plant Oils - pharmacology, Posterior Horn Cells - cytology, Posterior Horn Cells - metabolism, Rats, Somesthesis and somesthetic pathways (proprioception, exteroception, nociception), interoception, electrolocation. Sensory receptors, Stimulation, Chemical, Time Factors, Trigeminal Caudal Nucleus - cytology, Trigeminal Caudal Nucleus - metabolism, Vertebrates: nervous system and sense organs