Details

Autor(en) / Beteiligte

• Malairajan, P
• Gopalakrishnan, Geetha
• Narasimhan, S
• Veni, K Jessi Kala

Titel

Evalution of anti-ulcer activity of Polyalthia longifolia   (Sonn.) Thwaites in experimental animals

Ist Teil von

• Indian journal of pharmacology, 2008-05, Vol.40 (3), p.126-128

Ort / Verlag

India: Medknow Publications on behalf of Indian Pharmacological Society

Erscheinungsjahr

2008

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Objective: To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites. Materials and Methods: The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o. Results: A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer.Conclusion: This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.