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A bovine acellular scaffold for vocal fold reconstruction in a rat model
Journal of biomedical materials research. Part A, 2010-01, Vol.92A (1), p.18-32
Xu, Chet C.
Chan, Roger W.
Weinberger, Debra G.
Efune, Guy
Pawlowski, Karen S.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Xu, Chet C.
Chan, Roger W.
Weinberger, Debra G.
Efune, Guy
Pawlowski, Karen S.
Titel
A bovine acellular scaffold for vocal fold reconstruction in a rat model
Ist Teil von
Journal of biomedical materials research. Part A, 2010-01, Vol.92A (1), p.18-32
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
With a rat model of vocal fold injury, this study examined the in vivo host response to an acellular xenogeneic scaffold derived from the bovine vocal fold lamina propria, and the potential of the scaffold for constructive tissue remodeling. Bilateral wounds were created in the posterior vocal folds of 20 rats, and bovine acellular scaffolds were implanted into the wounds unilaterally, with the contralateral vocal folds as control. The rats were humanely sacrificed after 3 days, 7 days, 1 month, and 3 months, and the coronal sections of their larynges were examined histologically. Expressions of key matrix proteins including collagen I, collagen III, elastin, fibronectin, hyaluronic acid, and glycosaminoglycans (GAGs) were quantified with digital image analysis. Significant infiltration of host inflammatory cells and host fibroblasts in the scaffold implant was observed in the acute stage of wound repair (3 days and 7 days postsurgery). The mean relative densities of collagen I, collagen III, and GAGs in the implanted vocal folds were significantly higher than those in the control after 3 days, followed by gradual decreases over 3 months. Histological results showed that the scaffolds were apparently degraded by 3 months, with no fibrotic tissue formation or calcification. These preliminary findings suggested that the bovine acellular scaffold could be a potential xenograft for vocal fold regeneration. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296, 1552-4965
eISSN: 1552-4965
DOI: 10.1002/jbm.a.32279
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2787909
Format
–
Schlagworte
Animals
,
biocompatibility
,
Biological and medical sciences
,
Calcification
,
Cattle
,
Collagen
,
Collagen (type I)
,
Collagen (type III)
,
Digital imaging
,
Elastin
,
extracellular matrix scaffold
,
Fibronectin
,
Fibronectins - metabolism
,
foreign body response
,
Glycosaminoglycans
,
Guided Tissue Regeneration - methods
,
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
,
Hyaluronic acid
,
Image analysis
,
Image processing
,
Immunohistochemistry
,
Implants, Experimental
,
In vivo methods and tests
,
Inflammation
,
Lamina propria
,
larynx
,
Male
,
Medical sciences
,
Models, Animal
,
Otorhinolaryngology. Stomatology
,
Prosthesis Implantation
,
Rats
,
Rats, Sprague-Dawley
,
Scaffolds
,
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
,
Surgery of the upper aerodigestive tract
,
Tissue Scaffolds - chemistry
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
,
Vocal Cords - pathology
,
Vocal Cords - physiology
,
Vocal organs
,
Wound healing
,
Xenotransplantation
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