Nature genetics, 2008-09, Vol.40 (9), p.1059-1061
- Behrens, Timothy W
- Lessard, Christopher J
- Cotsapas, Chris
- Burtt, Noel P
- Vyse, Timothy J
- Davies, Leela
- Hackett, Rachel
- Leon, Joanlise M
- Rioux, John D
- Daly, Mark J
- Altshuler, David
- Gaffney, Patrick M
- Cunninghame Graham, Deborah
- Plenge, Robert M
- Graham, Robert R
- Parkin, Melissa
- Gates, Casey
- Moser, Kathy L
- Wither, Joan E
- Fortin, Paul R
- Guiducci, Candace
- Wong, Andrew K
2008
Details
- Autor(en) / Beteiligte
- Behrens, Timothy W
- Lessard, Christopher J
- Cotsapas, Chris
- Burtt, Noel P
- Vyse, Timothy J
- Davies, Leela
- Hackett, Rachel
- Leon, Joanlise M
- Rioux, John D
- Daly, Mark J
- Altshuler, David
- Gaffney, Patrick M
- Cunninghame Graham, Deborah
- Plenge, Robert M
- Graham, Robert R
- Parkin, Melissa
- Gates, Casey
- Moser, Kathy L
- Wither, Joan E
- Fortin, Paul R
- Guiducci, Candace
- Wong, Andrew K
- Titel
- Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
- Ist Teil von
- Nature genetics, 2008-09, Vol.40 (9), p.1059-1061
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 × 10−12, OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.200Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2772171
- Format
- –
- Schlagworte
- Arthritis, Rheumatoid - genetics, Autoimmune diseases, Biological and medical sciences, Chromosomes, Chromosomes, Human, Pair 6, Classical genetics, quantitative genetics, hybrids, DNA-Binding Proteins, Fundamental and applied biological sciences. Psychology, Genetic aspects, Genetic Predisposition to Disease, Genetic variation, Genetics, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Health aspects, Humans, Intracellular Signaling Peptides and Proteins - genetics, Lupus, Lupus Erythematosus, Systemic - genetics, Medical research, Medical sciences, Methods, theories and miscellaneous, Nuclear Proteins - genetics, Polymorphism, Single Nucleotide, Rheumatoid arthritis, Risk factors, Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis, Studies, Systemic lupus erythematosus, Tumor necrosis factor, Tumor Necrosis Factor alpha-Induced Protein 3