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P11-05. Induction of CD8+ T cell mediated immune responses through skin and mucosa: identification of immunostimulatory versus tolerogenic dendritic cells
Alternatively, using conditional ablation of LC in Langerin-DTR mice and the contact sensitizer DNFB (which modifies self proteins), we showed that epithelial LC are dispensable for priming CD8+ CTL mediating delayed-type hypersensitivity responses. [...] using a structurally related but tolerogenic hapten, DNTB, we demonstrated that LC migrate to draining lymph nodes for Ag presentation to CD8+ T cells, but were unable to prime CTL.