Details

Autor(en) / Beteiligte

• Dubois, B
• de Aguero, M Gomez
• Le Borgne, M
• Gouanvic, M
• Vocanson, M
• Kaiserlian, D

Titel

P11-05. Induction of CD8+ T cell mediated immune responses through skin and mucosa: identification of immunostimulatory versus tolerogenic dendritic cells

Ist Teil von

• Retrovirology, 2009-10, Vol.6 (Suppl 3), p.P150-P150, Article P150

Ort / Verlag

London: BioMed Central

Erscheinungsjahr

2009

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Alternatively, using conditional ablation of LC in Langerin-DTR mice and the contact sensitizer DNFB (which modifies self proteins), we showed that epithelial LC are dispensable for priming CD8+ CTL mediating delayed-type hypersensitivity responses. [...] using a structurally related but tolerogenic hapten, DNTB, we demonstrated that LC migrate to draining lymph nodes for Ag presentation to CD8+ T cells, but were unable to prime CTL.