The AAPS journal, 2008, Vol.10 (1), p.213-226
2008
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds
- Ist Teil von
- The AAPS journal, 2008, Vol.10 (1), p.213-226
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The goal of this study was to apply gastrointestinal simulation technology and integration of physiological parameters to predict biopharmaceutical drug classification. GastroPlus® was used with experimentally determined physicochemical and pharmacokinetic drug properties to simulate the absorption of several weak acid and weak base BCS class II compounds. Simulation of oral drug absorption given physicochemical drug properties and physicochemical parameters will aid justification of biowaivers for selected BCS class II compounds.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1550-7416eISSN: 1550-7416DOI: 10.1208/s12248-008-9023-xTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2751468
- Format
- –
- Schlagworte
- Beyond Guest Editors: James E. Polli, Biochemistry, Biological Availability, Biomedical and Life Sciences, Biomedicine, Biopharmaceutics Classification System, Biotechnology, Computer Simulation, Gastrointestinal Tract - drug effects, Gastrointestinal Tract - metabolism, Intestinal Absorption - drug effects, Intestinal Absorption - physiology, Permeability, Pharmaceutical Preparations - metabolism, Pharmacology/Toxicology, Pharmacy, Reproducibility of Results, Research Article/Themed Issue: Bioequivalence, Solubility, Themed Issue: Bioequivalence, Biopharmaceutics Classification System, and Beyond Guest Editors: James E. Polli