Details

Autor(en) / Beteiligte

• Meigs, James B
• Shrader, Peter
• Sullivan, Lisa M
• McAteer, Jarred B
• Fox, Caroline S
• Dupuis, Josée
• Manning, Alisa K
• Florez, Jose C
• Wilson, Peter W.F
• D'Agostino, Ralph B
• Cupples, L. Adrienne

Titel

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

Ist Teil von

• The New England journal of medicine, 2008-11, Vol.359 (21), p.2208-2219

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The authors of this study genotyped single-nucleotide polymorphisms (SNPs) at 18 diabetes-associated loci in participants of the Framingham Offspring Study. A genotype score based on these risk alleles predicted new cases of diabetes but resulted in only a slightly better prediction of risk than knowledge of common risk factors alone. In this study, a genotype score based on 18 diabetes-associated loci predicted new cases of diabetes but resulted in only a slightly better prediction of risk than knowledge of common risk factors alone. Type 2 diabetes mellitus is a major health problem worldwide. 1 Fortunately, its development can be prevented in many instances, 2 and persons at risk can be readily identified with the measurement of a few common risk factors. 3 – 5 Type 2 diabetes is heritable, with a risk for people with familial diabetes as compared with those without familial diabetes that is increased by a factor of 2 to 6. 6 , 7 Recent genetic association studies have provided convincing evidence that several novel loci are associated with the risk of diabetes, 8 – 13 each with a 5 to 37% increase in the relative odds of . . .