FEBS letters, 2009-06, Vol.583 (12), p.1817-1824
2009
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- Autor(en) / Beteiligte
- Titel
- IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis
- Ist Teil von
- FEBS letters, 2009-06, Vol.583 (12), p.1817-1824
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2009
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1, which participates in protein–protein interactions and integrates diverse signaling pathways. IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined. Proteins that bind IQGAP1 include Cdc42 and Rac1, E-cadherin, β-catenin, calmodulin and components of the mitogen-activated protein kinase pathway, all of which are involved in cancer. Here, we summarize the biological functions of IQGAPs that may contribute to neoplasia. Additionally, we review published data which implicate IQGAPs in cancer and tumorigenesis. The cumulative evidence suggests IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2009.05.007Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2743239
- Format
- –
- Schlagworte
- adenomatous polyposis coli, APC, beta Catenin - metabolism, Cancer, casein kinase 1, Cell Adhesion, Cell Movement, Cell Proliferation, CK1, ECM, EGF, epidermal growth factor, ERK, Exocytosis, extracellular matrix, extracellular signal-regulated kinase, FGF, fibroblast growth factor, GAP, Genes, Tumor Suppressor, glycogen synthase kinase-3β, GSK-3β, GTPase-activating protein, GTPase-Activating Proteins - chemistry, GTPase-Activating Proteins - genetics, GTPase-Activating Proteins - metabolism, HCC, hepatocellular carcinoma, Humans, IQGAP1, IQGAP2, IQGAP3, MAP Kinase Signaling System, MAPK, MAPK kinase, matrix metalloproteinase, MEK, Metastasis, mitogen-activated protein kinase, MMP, Molecular Structure, Neoplasia, Neoplasm Metastasis - genetics, Neoplasm Metastasis - physiopathology, Neoplasm Proteins - chemistry, Neoplasm Proteins - genetics, Neoplasm Proteins - metabolism, Neoplasms - etiology, Neoplasms - genetics, Neoplasms - metabolism, Oncogenes, Protein Binding, Protein Structure, Tertiary, ras GTPase-Activating Proteins - chemistry, ras GTPase-Activating Proteins - genetics, ras GTPase-Activating Proteins - metabolism, Transcription, Genetic, Tumorigenesis, vascular endothelial-derived growth factor, VEGF