Neuroscience, 2009-01, Vol.158 (2), p.369-372
2009
Details
- Autor(en) / Beteiligte
- Titel
- Phosphorylation of ΔFosB mediates its stability in vivo
- Ist Teil von
- Neuroscience, 2009-01, Vol.158 (2), p.369-372
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- Abstract The transcription factor, ΔFosB, accumulates in a region-specific manner in brain in response to many types of chronic stimulation due to the unusual stability of the protein. The phosphorylation of Ser27 in ΔFosB has been shown to promote this stability in vitro. We show here that this phosphorylation reaction is also important for ΔFosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2008.10.059Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2734485
- Format
- –
- Schlagworte
- Biological and medical sciences, casein kinase 2, cocaine, Fundamental and applied biological sciences. Psychology, Medical sciences, Neurology, Neuropharmacology, nucleus accumbens, Pharmacology. Drug treatments, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Vertebrates: nervous system and sense organs, viral gene transfer