Details

Autor(en) / Beteiligte

• Papp, Maria
• Foldi, Ildiko
• Altorjay, Istvan
• Palyu, Eszter
• Udvardy, Miklos
• Tumpek, Judit
• Sipka, Sandor
• Korponay-Szabo, Ilma Rita
• Nemes, Eva
• Veres, Gabor
• Dinya, Tamas
• Tordai, Attila
• Andrikovics, Hajnalka
• Norman, Gary L
• Lakatos, Peter Laszlo

Titel

Anti-microbial antibodies in celiac disease： Trick or treat

Ist Teil von

• World journal of gastroenterology : WJG, 2009-08, Vol.15 (31), p.3891-3900

Ort / Verlag

United States: Celiac Disease Center, Heim Pal Children's Hospital, Budapest, H-1089, Hungary%Department of Pediatrics, University of Debrecen, Debrecen, H-4032, Hungary%1st Department of Pediatrics, Semmelweis University, Budapest, H-1083, Hungary%Institute of Surgery, University of Debrecen, Debrecen, H-4032, Hungary%Department of Molecular Diagnostics, Hungarian National Blood Transfusion Service,Budapest, H-1113, Hungary%INOVA Diagnostics, Inc., San Diego, CA 92131-1638, United States%1st Department of Medicine, Semmelweis University, Budapest, H-1083, Hungary

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• AIM： To determine the prevalence of a new set ot anti-glycan and anti-outer membrane protein （anti- OMP） antibodies in a Hungarian cohort of adult Celiac disease （CD） patients. METHODS： 190 consecutive CD patients [M/F： 71/119, age：39.9 （SD：14.1） years], 100 healthy, and 48 gastrointestinal controls were tested for glycan anti-Saccharomyces cerevisiae （gASCA）, anti-laminaribioside （ALCA）, anti-chitobioside, anti-mannobioside, anti-OMP antibodies and major NOD2/CARD15 mutations. Thirty out of 82 CD patients enrolled at the time of diagnosis were re-evaluated for the same antibodies after longstanding gluten-free diet （GFD）. RESULTS： 65.9% of the CD patients were positive for at least one of the tested antibodies at the time of the diagnosis. Except anti-OMP and ALCA, antimicrobial antibodies were exclusively seen in untreated CD; however, the overall sensitivity was low. Any glycan positivity （LR＋： 3.13; 95% CI： 2.08-4.73） was associated with an increased likelihood ratio for diagnosing CD. Significant correlation was found between the levels of anti-glycan and anti-endomysial or anti-transglutaminase antibodies. Anti-glycan positivity was lost after longstanding GFD. Anti-glycan antibody titers were associated with symptoms at presentation, but not the presence of NOD2/CARD15 mutations. Patients with severe malabsorption more frequently had multiple antibodies at diagnosis （P = 0.019）. CONCLUSION： The presence of anti-glycan antibodies in CD seems to be secondary to the impaired small bowel mucosa which can lead to increased antigen presentation. Furthermore, anti-glycan positivity may be considered an additional marker of CD and dietary adherence.