Details

Autor(en) / Beteiligte

• Rawlins, Emma L.
• Okubo, Tadashi
• Xue, Yan
• Brass, David M.
• Auten, Richard L.
• Hasegawa, Hiroshi
• Wang, Fan
• Hogan, Brigid L.M.

Titel

The Role of Scgb1a1 + Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

Ist Teil von

• Cell stem cell, 2009-06, Vol.4 (6), p.525-534

Ort / Verlag

Cambridge, MA: Elsevier Inc

Erscheinungsjahr

2009

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• To directly test the contribution of Scgb1a1 + Clara cells to postnatal growth, homeostasis, and repair of lung epithelium, we generated a Scgb1a1-CreER TM “knockin” mouse for lineage-tracing these cells. Under all conditions tested, the majority of Clara cells in the bronchioles both self-renews and generates ciliated cells. In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively. Nevertheless, they can contribute to tracheal repair. In the postnatal mouse lung, it has been proposed that bronchioalveolar stem cells (BASCs) which coexpress Scgb1a1 ( Secretoglobin1a1) and SftpC ( Surfactant Protein C), contribute descendants to both bronchioles and alveoli. The putative BASCs were lineage labeled in our studies. However, we find no evidence for the function of a special BASC population during postnatal growth, adult homeostasis, or repair. Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells.