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The Role of Scgb1a1 + Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium
Ist Teil von
Cell stem cell, 2009-06, Vol.4 (6), p.525-534
Ort / Verlag
Cambridge, MA: Elsevier Inc
Erscheinungsjahr
2009
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
To directly test the contribution of Scgb1a1
+ Clara cells to postnatal growth, homeostasis, and repair of lung epithelium, we generated a
Scgb1a1-CreER
TM
“knockin” mouse for lineage-tracing these cells. Under all conditions tested, the majority of Clara cells in the bronchioles both self-renews and generates ciliated cells. In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively. Nevertheless, they can contribute to tracheal repair. In the postnatal mouse lung, it has been proposed that bronchioalveolar stem cells (BASCs) which coexpress
Scgb1a1 (
Secretoglobin1a1) and
SftpC (
Surfactant Protein C), contribute descendants to both bronchioles and alveoli. The putative BASCs were lineage labeled in our studies. However, we find no evidence for the function of a special BASC population during postnatal growth, adult homeostasis, or repair. Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells.