Details

Autor(en) / Beteiligte

• Zamore, Phillip D
• Ghildiyal, Megha

Titel

Small silencing RNAs: an expanding universe

Ist Teil von

• Nature reviews. Genetics, 2009-02, Vol.10 (2), p.94-108

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.