Nature neuroscience, 2009-02, Vol.12 (2), p.200-209
2009
Details
- Autor(en) / Beteiligte
- Titel
- CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
- Ist Teil von
- Nature neuroscience, 2009-02, Vol.12 (2), p.200-209
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Psychology & Behavioral Sciences Collection
- Beschreibungen/Notizen
- Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed by chronic, but not acute, antidepressant treatment. However, although the anxiety phenotype and its reversal by antidepressant treatment were CREB-dependent, the anhedonia-like symptoms were not mediated by CREB in NAcSh. We found that decreased CREB activity in NAcSh correlated with increased expression of certain K(+) channels and reduced electrical excitability of NAcSh neurons, which was sufficient to induce anxiety-like behaviors and was reversed by chronic antidepressant treatment. Together, our results describe a model that distinguishes anxiety- and depression-like behavioral phenotypes, establish a selective role of decreased CREB activity in NAcSh in anxiety-like behavior, and provide a mechanism by which antidepressant treatment alleviates anxiety symptoms after social isolation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn.2257Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2721778
- Format
- –
- Schlagworte
- Adrenergic Uptake Inhibitors - pharmacology, Affective Symptoms - drug therapy, Affective Symptoms - genetics, Affective Symptoms - physiopathology, Animals, Anxiety - drug therapy, Anxiety - genetics, Anxiety - physiopathology, Behavior, Animal - drug effects, Behavior, Animal - physiology, Cellular proteins, CREB-Binding Protein - physiology, Depression, Mental, Female, Gene expression, Gene Expression Profiling, Genetic aspects, Imipramine - pharmacology, Lac Operon, Life Sciences, Male, Mice, Mice, Transgenic, Neurons and Cognition, Nucleus Accumbens - physiology, Physiological aspects, Potassium Channels - physiology, Rats, Rats, Sprague-Dawley, Risk factors, Sexual Behavior, Animal - drug effects, Sexual Behavior, Animal - physiology, Social Isolation