Details

Autor(en) / Beteiligte

• Pitta, Maira G R
• Romano, Audrey
• Cabantous, Sandrine
• Henri, Sandrine
• Hammad, Awad
• Kouriba, Bouréma
• Argiro, Laurent
• el Kheir, Musa
• Bucheton, Bruno
• Mary, Charles
• El-Safi, Sayda Hassan
• Dessein, Alain

Titel

IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani

Ist Teil von

• The Journal of clinical investigation, 2009-08, Vol.119 (8), p.2379-2387

Ort / Verlag

United States: American Society for Clinical Investigation

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have demonstrated a crucial role of IL-17 and IL-22 in protection against infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-gamma. Analysis of Th1, Th2, and Th17 cytokine responses by cultured PBMCs from individuals in a cohort of subjects who developed KA or were protected against KA during a severe outbreak showed that IL-17 and IL-22 were strongly and independently associated with protection against KA. Our results suggest that, along with Th1 cytokines, IL-17 and IL-22 play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.