Nature genetics, 2008-06, Vol.40 (6), p.710-712
- Ouwehand, Willem
- Keniry, Andrew
- Fisher, Sheila A
- Jewell, Derek P
- Anderson, Carl A
- Prescott, Natalie J
- Deloukas, Panos
- Blaszczyk, Katarzyna
- Mansfield, John C
- Mathew, Christopher G
- Watkins, Nick
- Drummond, Hazel
- Cummings, Fraser R
- Forbes, Alastair
- Barrett, Jeffrey C
- Ravindrarajah, Radhi
- Sanderson, Jeremy
- Inouye, Mike
- Hunt, Sarah
- Nimmo, Elaine R
- Johnson, Christopher
- Bumpstead, Suzannah
- Hanson, Catherine E
- Lobo, Alan
- Massey, Dunecan
- Cardon, Lon
- Ewels, Philip
- Satsangi, Jack
- Tremelling, Mark
- Gwilliam, Rhian
- Carter, Martyn
- Berzuini, Carlo
- Lees, Charlie W
- Onnie, Clive M
- Parkes, Miles
- Lewis, Cathryn M
2008
Details
- Autor(en) / Beteiligte
- Ouwehand, Willem
- Keniry, Andrew
- Fisher, Sheila A
- Jewell, Derek P
- Anderson, Carl A
- Prescott, Natalie J
- Deloukas, Panos
- Blaszczyk, Katarzyna
- Mansfield, John C
- Mathew, Christopher G
- Watkins, Nick
- Drummond, Hazel
- Cummings, Fraser R
- Forbes, Alastair
- Barrett, Jeffrey C
- Ravindrarajah, Radhi
- Sanderson, Jeremy
- Inouye, Mike
- Hunt, Sarah
- Nimmo, Elaine R
- Johnson, Christopher
- Bumpstead, Suzannah
- Hanson, Catherine E
- Lobo, Alan
- Massey, Dunecan
- Cardon, Lon
- Ewels, Philip
- Satsangi, Jack
- Tremelling, Mark
- Gwilliam, Rhian
- Carter, Martyn
- Berzuini, Carlo
- Lees, Charlie W
- Onnie, Clive M
- Parkes, Miles
- Lewis, Cathryn M
- Titel
- Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
- Ist Teil von
- Nature genetics, 2008-06, Vol.40 (6), p.710-712
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.145Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2719289
- Format
- –
- Schlagworte
- Autophagy-Related Proteins, Biological and medical sciences, Biomarkers - metabolism, Biomedical research, Bowel disease, Carrier Proteins - genetics, Case-Control Studies, Cohort Studies, Colitis, Ulcerative - epidemiology, Colitis, Ulcerative - genetics, Colorectal cancer, Crohn Disease - epidemiology, Crohn Disease - genetics, Crohn's disease, Crohns disease, Diagnosis, Extracellular Matrix Proteins - genetics, Fundamental and applied biological sciences. Psychology, Gastroenterology. Liver. Pancreas. Abdomen, Gene loci, Genetic aspects, Genetic Predisposition to Disease, Genetics, Genetics of eukaryotes. Biological and molecular evolution, GTP-Binding Proteins - genetics, HLA-A Antigens - genetics, Homeodomain Proteins - genetics, Humans, Inflammatory bowel disease, Interleukin-12 Subunit p40 - genetics, Intracellular Signaling Peptides and Proteins, Medical research, Medical sciences, Nod2 Signaling Adaptor Protein - genetics, Other diseases. Semiology, Physiological aspects, Polymorphism, Single Nucleotide - genetics, Protein Serine-Threonine Kinases - genetics, Receptors, Interleukin - genetics, Regression analysis, Risk Factors, Single nucleotide polymorphisms, Stomach. Duodenum. Small intestine. Colon. Rectum. Anus, Ulcerative colitis