Details

Autor(en) / Beteiligte

• Fowler, Joanna S
• Alia-Klein, Nelly
• Kriplani, Aarti
• Logan, Jean
• Williams, Benjamin
• Zhu, Wei
• Craig, Ian W
• Telang, Frank
• Goldstein, Rita
• Volkow, Nora D
• Vaska, Paul
• Wang, Gene-Jack

Titel

Evidence That Brain MAO A Activity Does Not Correspond to MAO A Genotype in Healthy Male Subjects

Ist Teil von

• Biological psychiatry (1969), 2007-08, Vol.62 (4), p.355-358

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Background A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects. Methods Brain MAO A activity was measured with positron emission tomography and [11 C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism. Results There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes. Conclusions The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.