Details

Autor(en) / Beteiligte

• Potapova, Irina A., PhD
• Doronin, Sergey V., PhD
• Kelly, Damon J., PhD
• Rosen, Amy B., BS
• Schuldt, Adam J.T., BA
• Lu, Zhongju, PhD
• Guo, Yuanjian, MD
• Kochupura, Paul V., MD
• Robinson, Richard B., PhD
• Rosen, Michael R., MD
• Brink, Peter R., PhD
• Gaudette, Glenn R., PhD
• Cohen, Ira S., MD, PhD

Titel

Replacing damaged myocardium

Ist Teil von

• Journal of electrocardiology, 2007-11, Vol.40 (6), p.S199-S201

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2007

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Abstract Heart failure survival after diagnosis has barely changed for more than half a century. Recently, investigation has focused on differentiation of stem cells in vitro and their delivery for use in vivo as replacement cardiac contractile elements. Here we report preliminary results using mesenchymal stem cells partially differentiated to a cardiac lineage in vitro. When delivered to the canine heart on an extracellular matrix patch to replace a full-thickness ventricular defect in vivo, they improve regional mechanical function. The delivered cells were also tracked, and some became myocytes with mature sarcomeres.