Nature genetics, 2008-12, Vol.40 (12), p.1407-1409
2008
Details
- Autor(en) / Beteiligte
- Titel
- Common 5p15.33 and 6p21.33 variants influence lung cancer risk
- Ist Teil von
- Nature genetics, 2008-12, Vol.40 (12), p.1407-1409
- Ort / Verlag
- New York, NY: Nature Publishing Group
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 × 10−12), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; Pcombined = 4.97 × 10−10) and 5p15.33 (rs401681, CLPTM1L; Pcombined = 7.90 × 10−9).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.273Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2695928
- Format
- –
- Schlagworte
- Apoptosis, Biological and medical sciences, Carcinoma, Non-Small-Cell Lung - genetics, Case-Control Studies, Chromosome mapping, Chromosomes, Human, Pair 5 - genetics, Chromosomes, Human, Pair 6 - genetics, Confidence intervals, Data collection, Fundamental and applied biological sciences. Psychology, Genetic aspects, Genetic Predisposition to Disease, Genetics, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Genotype & phenotype, Humans, Inflation, Lung cancer, Lung Neoplasms - genetics, Medical research, Medical sciences, Methods, Pneumology, Polymorphism, Single Nucleotide, Quality control, Risk, Risk factors, Sample size, Single nucleotide polymorphisms, Tumors of the respiratory system and mediastinum