Nature genetics, 2007-12, Vol.39 (12), p.1431-1433
2007
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- Autor(en) / Beteiligte
- Titel
- Rheumatoid arthritis association at 6q23
- Ist Teil von
- Nature genetics, 2007-12, Vol.39 (12), p.1431-1433
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α-induced protein 3 (TNFAIP3).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.2007.32Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2674282
- Format
- –
- Schlagworte
- Arthritis, Rheumatoid - genetics, Biological and medical sciences, Chromosomes, Human, Pair 6, Classical genetics, quantitative genetics, hybrids, Diagnosis, Diseases of the osteoarticular system, DNA binding proteins, Female, Fundamental and applied biological sciences. Psychology, Genes, Genetic aspects, Genetic Predisposition to Disease, Genetics of eukaryotes. Biological and molecular evolution, Genome, Human, Genomics, Humans, Inflammatory joint diseases, Linkage Disequilibrium, Male, Medical sciences, Methods, theories and miscellaneous, Physiological aspects, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics, Proteins, Rheumatoid arthritis, Risk factors, Single nucleotide polymorphisms, Tumors, Validation studies