The Journal of neuroscience, 2008-12, Vol.28 (53), p.14537-14545
2008
Details
- Autor(en) / Beteiligte
- Titel
- Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
- Ist Teil von
- The Journal of neuroscience, 2008-12, Vol.28 (53), p.14537-14545
- Ort / Verlag
- United States: Society for Neuroscience
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Amyloid-beta (Abeta) peptides are produced in high amounts during Alzheimer's disease, causing synaptic and memory dysfunction. However, they are also released in lower amounts in normal brains throughout life during synaptic activity. Here we show that low picomolar concentrations of a preparation containing both Abeta(42) monomers and oligomers cause a marked increase of hippocampal long-term potentiation, whereas high nanomolar concentrations lead to the well established reduction of potentiation. Picomolar levels of Abeta(42) also produce a pronounced enhancement of both reference and contextual fear memory. The mechanism of action of picomolar Abeta(42) on both synaptic plasticity and memory involves alpha7-containing nicotinic acetylcholine receptors. These findings strongly support a model for Abeta effects in which low concentrations play a novel positive, modulatory role on neurotransmission and memory, whereas high concentrations play the well known detrimental effect culminating in dementia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0270-6474eISSN: 1529-2401DOI: 10.1523/JNEUROSCI.2692-08.2008Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2673049
- Format
- –
- Schlagworte
- 2-Amino-5-phosphonovalerate - pharmacology, alpha7 Nicotinic Acetylcholine Receptor, Amyloid beta-Peptides - pharmacology, Analysis of Variance, Animals, Bungarotoxins - pharmacology, Dose-Response Relationship, Drug, Electric Stimulation - methods, Excitatory Amino Acid Antagonists - pharmacology, Excitatory Postsynaptic Potentials - drug effects, Excitatory Postsynaptic Potentials - genetics, Hippocampus - cytology, Humans, In Vitro Techniques, Male, Maze Learning - drug effects, Mecamylamine - pharmacology, Memory - drug effects, Mice, Mice, Inbred C57BL, Mice, Knockout, Neuronal Plasticity - drug effects, Neuronal Plasticity - genetics, Nicotinic Antagonists - pharmacology, Patch-Clamp Techniques, Peptide Fragments - pharmacology, Receptors, Nicotinic - deficiency, Synapses - drug effects