Cancer cell, 2009-02, Vol.15 (2), p.135-147
2009
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- Autor(en) / Beteiligte
- Titel
- Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
- Ist Teil von
- Cancer cell, 2009-02, Vol.15 (2), p.135-147
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133 + cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1. These cells have a distinct expression profile that suggests increased proliferative capacity and decreased tendency to undergo apoptosis and differentiation. CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15 + cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1535-6108eISSN: 1878-3686DOI: 10.1016/j.ccr.2008.12.016Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2664097
- Format
- –
- Schlagworte
- AC133 Antigen, Animals, Antigens, CD - metabolism, Basic Helix-Loop-Helix Transcription Factors - genetics, Basic Helix-Loop-Helix Transcription Factors - metabolism, Biomarkers, Tumor, Brain Neoplasms - pathology, Brain Neoplasms - physiopathology, CELLCYCLE, Disease Models, Animal, Gene Expression Profiling, Glycoproteins - metabolism, Hedgehog Proteins - genetics, Hedgehog Proteins - metabolism, Humans, Lewis X Antigen - genetics, Lewis X Antigen - metabolism, Medulloblastoma - pathology, Medulloblastoma - physiopathology, Mice, Mice, Mutant Strains, Mice, SCID, Microarray Analysis, Molecular Sequence Data, Neoplasm Transplantation, Neoplastic Stem Cells - metabolism, Neoplastic Stem Cells - pathology, Neurons - cytology, Neurons - metabolism, Patched Receptors, Peptides - metabolism, Receptors, Cell Surface - genetics, Receptors, Cell Surface - metabolism, Recombinant Fusion Proteins - genetics, Recombinant Fusion Proteins - metabolism, Signal Transduction - physiology, Stem Cells - cytology, Stem Cells - metabolism, STEMCELL, Survival Rate, Tumor Cells, Cultured