Details

Autor(en) / Beteiligte

• Frayling, Timothy M
• Timpson, Nicholas J
• Weedon, Michael N
• Zeggini, Eleftheria
• Freathy, Rachel M
• Lindgren, Cecilia M
• Perry, John R.B
• Elliott, Katherine S
• Lango, Hana
• Rayner, Nigel W
• Shields, Beverley
• Harries, Lorna W
• Barrett, Jeffrey C
• Ellard, Sian
• Groves, Christopher J
• Knight, Bridget
• Patch, Ann-Marie
• Ness, Andrew R
• Ebrahim, Shah
• Lawlor, Debbie A
• Ring, Susan M
• Ben-Shlomo, Yoav
• Jarvelin, Marjo-Riitta
• Sovio, Ulla
• Bennett, Amanda J
• Melzer, David
• Ferrucci, Luigi
• Loos, Ruth J.F
• Barroso, Inês
• Wareham, Nicholas J
• Karpe, Fredrik
• Owen, Katharine R
• Cardon, Lon R
• Walker, Mark
• Hitman, Graham A
• Palmer, Colin N.A
• Doney, Alex S.F
• Morris, Andrew D
• Smith, George Davey
• Hattersley, Andrew T
• McCarthy, Mark I

Titel

Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Ist Teil von

• Science (American Association for the Advancement of Science), 2007-05, Vol.316 (5826), p.889-894

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2007

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.