Virology (New York, N.Y.), 2008-10, Vol.380 (2), p.173-181
2008
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- Autor(en) / Beteiligte
- Titel
- BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex
- Ist Teil von
- Virology (New York, N.Y.), 2008-10, Vol.380 (2), p.173-181
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract In this study we provide evidence that the transcription factor BCL11B represses expression from the HIV-1 long terminal repeat (LTR) in T lymphocytes through direct association with the HIV-1 LTR. We also demonstrate that the NuRD corepressor complex mediates BCL11B transcriptional repression of the HIV-1 LTR. In addition, BCL11B and the NuRD complex repressed TAT-mediated transactivation of the HIV-1 LTR in T lymphocytes, pointing to a potential role in initiation of silencing. In support of all the above results, we demonstrate that BCL11B affects HIV-1 replication and virus production, most likely by blocking LTR transcriptional activity. BCL11B showed specific repression for the HIV-1 LTR sequences isolated from seven different HIV-1 subtypes, demonstrating that it is a general transcriptional repressor for all LTRs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0042-6822eISSN: 1096-0341DOI: 10.1016/j.virol.2008.07.035Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2637995
- Format
- –
- Schlagworte
- Artificial Gene Fusion, BCL11B, Cell Line, CTIP2, DNA-Binding Proteins - metabolism, Gene Expression Regulation, Viral, Genes, Reporter, Histone Deacetylases - metabolism, HIV, HIV Long Terminal Repeat, HIV-1 - physiology, HIV-1 subtypes, Human immunodeficiency virus 1, Humans, Infectious Disease, LTR, Luciferases - biosynthesis, Luciferases - genetics, Mi-2 Nucleosome Remodeling and Deacetylase Complex, NuRD complex, Protein Binding, Repressor Proteins - metabolism, T lymphocytes, T-Lymphocytes - immunology, T-Lymphocytes - virology, TAT, tat Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors, Transcriptional repression, Tumor Suppressor Proteins - metabolism, Virus Replication