Details

Autor(en) / Beteiligte

• Beeson, James G.
• Mann, Emily J.
• Elliott, Salenna R.
• Lema, Valentino M.
• Tadesse, Eyob
• Molyneux, Malcolm E.
• Brown, Graham V.
• Rogerson, Stephen J.

Titel

Antibodies to Variant Surface Antigens of Plasmodium falciparum–Infected Erythrocytes and Adhesion Inhibitory Antibodies Are Associated with Placental Malaria and Have Overlapping and Distinct Targets

Ist Teil von

• The Journal of infectious diseases, 2004-02, Vol.189 (3), p.540-551

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2004

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We measured antibodies to chondroitin sulfate A (CSA)–binding and placental Plasmodium falciparum–infected red blood cells (PRBCs) among pregnant women with or without placental malaria. Immunoglobulin G to PRBC surface antigens was rare in uninfected primigravidae (3.7%), more prevalent in infected primigravidae (70%; P<.001), and common in infected (77%) and uninfected (83%) multigravidae. Similar patterns were seen for agglutinating antibodies, and antibodies were similar among women with past or active placental infection. PRBC adhesion to CSA was inhibited 60% by cells obtained from infected primigravidae but 24% by cells obtained from uninfected primigravidae (P=.025), whereas infection did not alter adhesion inhibition by multigravidae (77% inhibition). There was substantial heterogeneity in antibody type and levels. Antibodies did not correlate with parasite density or pregnancy outcome. Comparisons between antibodies suggest that adhesion-inhibitory antibodies and those to PRBC variant antigens have distinct and overlapping epitopes, may be acquired independently, and have different roles in immunity