Details

Autor(en) / Beteiligte

• Klinge, Carolyn M.

Titel

Estrogenic control of mitochondrial function and biogenesis

Ist Teil von

• Journal of cellular biochemistry, 2008-12, Vol.105 (6), p.1342-1351

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Estrogens have cell‐specific effects on a variety of physiological endpoints including regulation of mitochondrial biogenesis and activity. Estrogens regulate gene transcription by the classical genomic mechanism of binding to estrogen receptors α and β (ERα and ERβ) as well as the more recently described nongenomic pathways involving plasma membrane‐associated ERs that activate intracellular protein kinase‐mediated phosphorylation signaling cascades. Here I will review the rapid and longer‐term effects of estrogen on mitochondrial function. The identification of ERα and ERβ within mitochondria of various cells and tissues is discussed with a model of estrogen regulation of the transcription of nuclear respiratory factor‐1 (NRF‐1, NRF1). NRF‐1 subsequently promotes transcription of mitochondrial transcription factor Tfam (mtDNA maintenance factor, also called mtTFA) and then Tfam targets mtDNA‐encoded genes. The nuclear effects of estrogens on gene expression directly controlling mitochondrial biogenesis, oxygen consumption, mtDNA transcription, and apoptosis are reviewed. Overall, we are just beginning to evaluate the many direct and indirect effects of estrogens on mitochondrial activities. J. Cell. Biochem. 105: 1342–1351, 2008. © 2008 Wiley‐Liss, Inc.