Clinical infectious diseases, 2008-08, Vol.47 (3), p.421-424
2008
Details
- Autor(en) / Beteiligte
- Titel
- Detection of Nonnucleoside Reverse-Transcriptase Inhibitor-Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy
- Ist Teil von
- Clinical infectious diseases, 2008-08, Vol.47 (3), p.421-424
- Ort / Verlag
- United States: The University of Chicago Press
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51–400 copies/mL and ⩽50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-4838eISSN: 1537-6591DOI: 10.1086/589867Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2586907
- Format
- –
- Schlagworte
- Adult, Antiretroviral drugs, Brief Report, Drug Administration Schedule, Drug resistance, Drug Resistance, Viral - genetics, Female, HIV, HIV Infections - drug therapy, HIV Infections - virology, HIV-1 - drug effects, HIV-1 - genetics, Human immunodeficiency virus, Human immunodeficiency virus 1, Humans, Male, Mutation, Mutation - drug effects, Reverse Transcriptase Inhibitors - administration & dosage, Ribonucleic acid, RNA, Viral Load