Vaccine, 2008-09, Vol.26 (41), p.5246-5254
2008
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- Autor(en) / Beteiligte
- Titel
- Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates
- Ist Teil von
- Vaccine, 2008-09, Vol.26 (41), p.5246-5254
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2008.07.057Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2582173
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Applied microbiology, Arenaviruses, Biological and medical sciences, Biomedical research, Callithrix, Callithrix - immunology, CD3 Complex - immunology, Chlorocebus aethiops, Enzymes, Female, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation - immunology, Genomes, Histology, Human viral diseases, Humans, Immunity, Cellular - immunology, Infectious diseases, Kinases, Lassa fever, Lassa Fever - immunology, Lassa Fever - pathology, Lassa Fever - prevention & control, Lassa fever and arenovirus diseases, Lassa virus - genetics, Lassa virus - immunology, Lassa virus - isolation & purification, Leukocytes, Mononuclear - immunology, Lipopolysaccharide Receptors - immunology, Male, Medical sciences, Microbiology, Monkeys & apes, Protection, Proteins, Reassortant Viruses - genetics, Reassortant Viruses - immunology, RNA polymerase, Safety, Studies, Survival Analysis, T-Lymphocytes - immunology, Tropical viral diseases, Vaccine, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vero Cells, Viral diseases, Viremia - immunology, Viruses