American journal of respiratory and critical care medicine, 2008-09, Vol.178 (6), p.558-564
2008
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Details
- Autor(en) / Beteiligte
- Titel
- The Cancer Paradigm of Severe Pulmonary Arterial Hypertension
- Ist Teil von
- American journal of respiratory and critical care medicine, 2008-09, Vol.178 (6), p.558-564
- Ort / Verlag
- New York, NY: Am Thoracic Soc
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The plexiform lesions of severe pulmonary arterial hypertension (PAH) are similar in histologic appearance, whether the disease is idiopathic or secondary. Both forms of the disease show actively proliferating endothelial cells without evidence of apoptosis. Here, we discuss the pathobiology of the atypical, angioproliferative endothelial cells in severe PAH. The concept of the endothelial cell as a "quasi-malignant" cell provides a new framework for antiproliferative, antiangiogenic therapy in severe PAH.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1073-449XeISSN: 1535-4970DOI: 10.1164/rccm.200709-1369PPTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2542431
- Format
- –
- Schlagworte
- Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Angiogenesis, Apoptosis, Biological and medical sciences, Bone marrow, Cancer therapies, Cell growth, Cell Proliferation, Dendritic cells, Disease, Endothelial Cells - pathology, Endothelial Cells - physiology, Gene Expression Regulation - physiology, Humans, Hypertension, Pulmonary - drug therapy, Hypertension, Pulmonary - pathology, Hypertension, Pulmonary - physiopathology, Hypoxia, Immunohistochemistry, Intensive care medicine, Medical sciences, Neoplasms - physiopathology, Pneumology, Pulmonary, Pulmonary arteries, Pulmonary Artery - pathology, Pulmonary hypertension, Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases, Shear stress, Smooth muscle, Terminology as Topic, Vascular endothelial growth factor, Vasoconstriction - physiology, Wnt Proteins - metabolism