Details

Autor(en) / Beteiligte

• Liu, Pengyuan
• Vikis, Haris G.
• Wang, Daolong
• Lu, Yan
• Wang, Yian
• Schwartz, Ann G.
• Pinney, Susan M.
• Yang, Ping
• de Andrade, Mariza
• Petersen, Gloria M.
• Wiest, Jonathan S.
• Fain, Pamela R.
• Gazdar, Adi
• Gaba, Colette
• Rothschild, Henry
• Mandal, Diptasri
• Coons, Teresa
• Lee, Juwon
• Kupert, Elena
• Seminara, Daniela
• Minna, John
• Bailey-Wilson, Joan E.
• Wu, Xifeng
• Spitz, Margaret R.
• Eisen, Timothy
• Houlston, Richard S.
• Amos, Christopher I.
• Anderson, Marshall W.
• You, Ming

Titel

Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer

Ist Teil von

• JNCI : Journal of the National Cancer Institute, 2008-09, Vol.100 (18), p.1326-1330

Ort / Verlag

Cary, NC: Oxford University Press

Erscheinungsjahr

2008

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.