Details

Autor(en) / Beteiligte

• Loussouarn, D
• Campion, L
• Sagan, C
• Frenel, J-S
• Dravet, F
• Classe, J-M
• Pioud-Martigny, R
• Berton-Rigaud, D
• Bourbouloux, E
• Mosnier, J-F
• Bataille, F-R
• Campone, M

Titel

Prognostic impact of syndecan-1 expression in invasive ductal breast carcinomas

Ist Teil von

• British journal of cancer, 2008-06, Vol.98 (12), p.1993-1998

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Carcinoma cells lack syndecan-1 expression when they are transiting from an epithelial to a less-differentiated mesenchymal phenotype (epithelial–mesenchymal transition, EMT). Furthermore, a shift of syndecan-1 expression from malignant epithelial cells to reactive stromal cells has also been observed during progression of many carcinomas. Finally, epithelial and/or stromal syndecan-1 expression is of prognostic value in many carcinomas. Because recent results are contradictory in breast carcinomas, we have re-evaluated the prognostic significance of syndecan-1 expression in a cohort of 80 patients with invasive ductal breast carcinomas. The tumours from 80 patients diagnosed with invasive ductal breast carcinomas were used to construct a tissue microarray, which was stained with syndecan-1 by immunohistochemistry. We correlated syndecan-1 expression with clinicopathologic parameters and relapse-free survival (RFS). Exclusive epithelial expression of syndecan-1 is observed in 61.25% of the patients, whereas exclusive stromal expression is observed in 30% of the patients. Only 8.75% of the patients had both stromal and epithelial expressions of syndecan-1. A significant correlation was found between the loss of syndecan-1 epithelial expression and the syndecan-1 stromal expression with high grade of malignancy ( P =0.011). The loss of syndecan-1 epithelial expression is correlated with RFS ( P =0.001). Using multivariate Cox analysis, loss of epithelial syndecan-1 expression was the only prognostic indicator ( P <0.001). We concluded that the loss of syndecan-1 epithelial expression was of strong prognostic value in breast carcinomas.