Details

Autor(en) / Beteiligte

• Seo, J. A.
• Kim, N. H.
• Park, S. Y.
• Kim, H. Y.
• Ryu, O. H.
• Lee, K. W.
• Lee, J.
• Kim, D. L.
• Choi, K. M.
• Baik, S. H.
• Choi, D. S.
• Kim, S. G.

Titel

Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease

Ist Teil von

• Clinical endocrinology (Oxford), 2008-04, Vol.68 (4), p.555-560

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2008

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Summary Objective  Retinol‐binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin‐resistant states. We investigated the relationship between non‐alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. Methods  One hundred and fifty‐nine nondiabetic, non‐alcoholic subjects (95 males and 64 females) participated in this study. Division of subjects into a NAFLD group (n = 73; 45 males and 28 females) or a normal group (n = 86; 50 males and 36 females) was based on the presence of fatty liver disease determined by sonography. Results  Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group (62·8 ± 16·0 mg/l vs. 51·7 ± 14·6 mg/l, P < 0·0001). Multiple logistic regression analysis revealed that the RBP4 level was an independent factor associated with NAFLD (P = 0·0042). In addition, serum RBP4 levels were positively correlated with serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ‐glutamyltranspeptidase (GGT) levels. The significant association between serum RBP4 and GGT levels remained even after adjusting for age, gender, body mass index, the homeostasis model of assessment (HOMA) value and the presence of NAFLD (r = 0·3097, P = 0·0002). Conclusion  Serum RBP4 levels are significantly associated with NAFLD and liver enzymes.