Details

Autor(en) / Beteiligte

• Scheeren, Ferenc A.
• Diehl, Sean A.
• Smit, Laura A.
• Beaumont, Tim
• Naspetti, Marianne
• Bende, Richard J.
• Blom, Bianca
• Karube, Kennosuke
• Ohshima, Koichi
• van Noesel, Carel J.M.
• Spits, Hergen

Titel

IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis

Ist Teil von

• Blood, 2008-05, Vol.111 (9), p.4706-4715

Ort / Verlag

Washington, DC: Elsevier Inc

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Classical Hodgkin lymphoma (HL) is a malignant disorder characterized by the presence of neoplastic mononucleated Hodgkin and multinucleated Reed-Sternberg cells. Here, we show that both the interleukin (IL)–21 receptor as well as IL-21 are expressed by HL cells. IL-21 activates signal transducer of activation and transcription 3 (STAT3) and STAT5 in HL cell lines and activated human B cells. Ectopic expression of constitutively active STAT5 in primary human B cells resulted in immortalized B cells that have lost the B-cell phenotype and strongly resembled HL cells, which could partially be rescued by ectopic expression of the B cell–determining transcription factor E47. Data from experiments using reporter assays and overexpression of constitutively active IKK2 support the hypothesis that the STAT5 and nuclear factor-κB (NF-κB) pathways colaborate in HL genesis.