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Genetic Predisposition to Self-Curing Infection with the Protozoan Leishmania chagasi: A Genome Wide Scan
Ist Teil von
The Journal of infectious diseases, 2007-09, Vol.196 (8), p.1261-1269
Erscheinungsjahr
2007
Link zum Volltext
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
The protozoan
Leishmania chagasi
can cause disseminated, fatal visceral leishmaniasis (VL) or asymptomatic human infection. We hypothesized that genetic factors contribute to this variable response to infection. A family study was performed in endemic neighborhoods near Natal, northeast Brazil. Subjects were assessed for VL or asymptomatic infection, defined as a positive delayed type hypersensitivity (DTH) skin test response to Leishmania antigen without disease symptoms. A genome scan of 405 microsatellite markers in 1254 subjects was analyzed for regions of linkage. The results indicated loci of potential linkage to DTH response on chromosomes 2, 13, 15 and 19, and a novel region of potential interest for VL on chromosome 9. An understanding of the genetic factors determining whether an individual will develop symptomatic or asymptomatic infection with
L. chagasi
may illuminate proteins essential for immune protection against this parasitic disease; findings could reveal strategies for immunotherapy or prevention.