The Journal of clinical investigation, 2003-11, Vol.112 (9), p.1300-1307
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
- Ist Teil von
- The Journal of clinical investigation, 2003-11, Vol.112 (9), p.1300-1307
- Ort / Verlag
- United States: American Society for Clinical Investigation
- Erscheinungsjahr
- 2003
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9738eISSN: 1558-8238DOI: 10.1172/jci200320074Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_228474
- Format
- –
- Schlagworte
- 4-Butyrolactone - analogs & derivatives, 4-Butyrolactone - antagonists & inhibitors, 4-Butyrolactone - physiology, Animals, Anti-Bacterial Agents - pharmacology, Antibiotics, Bacteria, Bacterial infections, Bacterial Infections - drug therapy, Biofilms, Biomedical research, Chronic Disease, Communication, Drugs, Furans - pharmacology, Gram-negative bacteria, Gram-positive bacteria, Humans, Infections, Infectious diseases, Organisms, RNA polymerase, Series, Signal Transduction - drug effects, Virulence