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Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans
Ist Teil von
The Journal of physiology, 1999-09, Vol.519 (3), p.911-921
Ort / Verlag
Oxford, UK: The Physiological Society
Erscheinungsjahr
1999
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The role of adrenaline in regulating hepatic glucose production and muscle glucose uptake during exercise was examined in
six adrenaline-deficient, bilaterally adrenalectomised humans. Six sex- and age-matched healthy individuals served as controls
(CON).
Adrenalectomised subjects cycled for 45 min at 68 ± 1 % maximum pulmonary O 2 uptake (VÌ O 2 ,max ), followed by 15 min at 84 ± 2 %VÌ O 2 ,max without (âADR) or with (+ADR) adrenaline infusion, which elevated plasma adrenaline levels (45 min, 4.49 ± 0.69 nmol l â1 ; 60 min, 12.41 ± 1.80 nmol l â1 ; means ± s.e.m.). Glucose kinetics were measured using [3- 3 H]glucose.
Euglycaemia was maintained during exercise in CON and âADR, whilst in +ADR plasma glucose was elevated. The exercise-induced
increase in hepatic glucose production was similar in +ADR and âADR; however, adrenaline infusion augmented the rise in hepatic
glucose production early in exercise. Glucose uptake increased during exercise in +ADR and âADR, but was lower and metabolic
clearance rate was reduced in +ADR.
During exercise noradrenaline and glucagon concentrations increased, and insulin and cortisol concentrations decreased, but
plasma levels were similar between trials. Adrenaline infusion suppressed growth hormone and elevated plasma free fatty acids,
glycerol and lactate. Alanine and β-hydroxybutyrate levels were similar between trials.
The results demonstrate that glucose homeostasis was maintained during exercise in adrenalectomised subjects. Adrenaline does
not appear to play a major role in matching hepatic glucose production to the increase in glucose clearance. In contrast,
adrenaline infusion results in a mismatch by simultaneously enhancing hepatic glucose production and inhibiting glucose clearance.