The Journal of physiology, 1998-09, Vol.511 (3), p.675-682
1998
Details
- Autor(en) / Beteiligte
- Titel
- Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia
- Ist Teil von
- The Journal of physiology, 1998-09, Vol.511 (3), p.675-682
- Ort / Verlag
- Oxford, UK: The Physiological Society
- Erscheinungsjahr
- 1998
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes ( elk1 ) was determined by cDNA cloning. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3751eISSN: 1469-7793DOI: 10.1111/j.1469-7793.1998.675bg.xTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2231163
- Format
- –
- Schlagworte
- Animals, Brain Chemistry - physiology, Cloning, Molecular, DNA, Complementary - isolation & purification, DNA-Binding Proteins, Ether-A-Go-Go Potassium Channels, ets-Domain Protein Elk-1, Ganglia, Sympathetic - chemistry, Gene Expression - physiology, Mammals, Molecular Sequence Data, Potassium Channels - genetics, Proto-Oncogene Proteins, Rapid Report, Rats, RNA, Messenger - analysis, Sciatic Nerve - chemistry, Sequence Homology, Amino Acid, Transcription Factors, Xenopus laevis