Details

Autor(en) / Beteiligte

• Chen, Thomas T
• Li, Li
• Chung, Dong-Hui
• Allen, Christopher D C
• Torti, Suzy V
• Torti, Frank M
• Cyster, Jason G
• Chen, Chih-Ying
• Brodsky, Frances M
• Niemi, Eréne C
• Nakamura, Mary C
• Seaman, William E
• Daws, Michael R

Titel

TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis

Ist Teil von

• The Journal of experimental medicine, 2005-10, Vol.202 (7), p.955-965

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• T cell immunoglobulin-domain and mucin-domain (TIM) proteins constitute a receptor family that was identified first on kidney and liver cells; recently it was also shown to be expressed on T cells. TIM-1 and -3 receptors denote different subsets of T cells and have distinct regulatory effects on T cell function. Ferritin is a spherical protein complex that is formed by 24 subunits of H- and L-ferritin. Ferritin stores iron atoms intracellularly, but it also circulates. H-ferritin, but not L-ferritin, shows saturable binding to subsets of human T and B cells, and its expression is increased in response to inflammation. We demonstrate that mouse TIM-2 is expressed on all splenic B cells, with increased levels on germinal center B cells. TIM-2 also is expressed in the liver, especially in bile duct epithelial cells, and in renal tubule cells. We further demonstrate that TIM-2 is a receptor for H-ferritin, but not for L-ferritin, and expression of TIM-2 permits the cellular uptake of H-ferritin into endosomes. This is the first identification of a receptor for ferritin and reveals a new role for TIM-2.