Details

Autor(en) / Beteiligte

• Tassaneetrithep, Boonrat
• Burgess, Timothy H
• Granelli-Piperno, Angela
• Trumpfheller, Christine
• Finke, Jennifer
• Sun, Wellington
• Eller, Michael A
• Pattanapanyasat, Kovit
• Sarasombath, Suttipant
• Birx, Deborah L
• Steinman, Ralph M
• Schlesinger, Sarah
• Marovich, Mary A

Titel

DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells

Ist Teil von

• The Journal of experimental medicine, 2003-04, Vol.197 (7), p.823-829

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2003

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti-DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.