Details

Autor(en) / Beteiligte

• Lebbink, Robert Jan
• de Ruiter, Talitha
• Adelmeijer, Jelle
• Brenkman, Arjan B
• van Helvoort, Joop M
• Koch, Manuel
• Farndale, Richard W
• Lisman, Ton
• Sonnenberg, Arnoud
• Lenting, Peter J
• Meyaard, Linde

Titel

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

Ist Teil von

• The Journal of experimental medicine, 2006-06, Vol.203 (6), p.1419-1425

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high affinity ligands for the broadly expressed inhibitory leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). The interaction is dependent on the conserved Gly-Pro-Hyp collagen repeats. Antibody cross-linking of LAIR-1 is known to inhibit immune cell function in vitro. We now show that collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro. Thus far, all documented ligands for immune inhibitory receptors are membrane molecules, implying a regulatory role in cell-cell interaction. Our data reveal a novel mechanism of peripheral immune regulation by inhibitory immune receptors binding to extracellular matrix collagens.