Journal of neurology, neurosurgery and psychiatry, 2007-09, Vol.78 (9), p.936-938
2007
Details
- Autor(en) / Beteiligte
- Titel
- CSF neurofilament proteins in the differential diagnosis of dementia
- Ist Teil von
- Journal of neurology, neurosurgery and psychiatry, 2007-09, Vol.78 (9), p.936-938
- Ort / Verlag
- London: BMJ Publishing Group Ltd
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Background: Neurofilament (NF) proteins are major cytoskeletal constituents of neurons. Increased CSF NF levels may reflect neuronal degeneration. Objective: To investigate the diagnostic value of CSF NF analysis to discriminate in relatively young dementia patients between frontotemporal lobe degeneration (FTLD) and early onset Alzheimer’s disease (EAD; onset ⩽65 years of age), and in elderly dementia patients between dementia with Lewy bodies (DLB) and late onset AD (LAD; onset >65 years of age). Methods: In CSF of 28 FTLD, 37 EAD, 18 DLB and 33 LAD patients, and 26 control subjects, we analysed NF light chain (NFL), phosphorylated NF heavy chain (pNFH), amyloid β42 protein (Aβ42), total tau and tau phosphorylated at threonine 181 (p-tau181). Results: CSF NFL levels were higher in FTLD patients compared with EAD patients (p<0.001), and diagnostic accuracy of p-tau181 and Aβ42 analysis improved with addition of NFL analysis (sensitivity 86%, specificity 100%). CSF pNFH levels were elevated in DLB, LAD and FTLD compared with controls (p<0.05) but no significant differences were found between the dementia groups. Conclusions: In the diagnostic workup of relatively young dementia patients, CSF NFL levels may play a role in the discrimination between FTLD and EAD, especially in combination with Aβ42 and p-tau181 analysis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3050eISSN: 1468-330XDOI: 10.1136/jnnp.2006.107326Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2117885
- Format
- –
- Schlagworte
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease - cerebrospinal fluid, Alzheimer Disease - diagnosis, Alzheimer’s disease, Amyloid beta-Peptides - cerebrospinal fluid, amyloid β42 protein, area under the curve, AUC, Aβ42, Biological and medical sciences, Case-Control Studies, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Dementia, Dementia - cerebrospinal fluid, Dementia - diagnosis, dementia with Lewy bodies, Diagnosis, Differential, Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes, DLB, EAD, early onset Alzheimer’s disease, Female, frontotemporal lobe degeneration, FTLD, Humans, LAD, late onset Alzheimer’s disease, Lewy Body Disease - cerebrospinal fluid, Lewy Body Disease - diagnosis, Male, Medical sciences, Middle Aged, Nervous system (semeiology, syndromes), neurofilament, neurofilament light chain, neurofilament medium chain, Neurofilament Proteins - cerebrospinal fluid, Neurology, NFL, NFM, p-tau181, phosphorylated neurofilament heavy chain, pNFH, Predictive Value of Tests, t-tau, tau phosphorylated at threonine 181, tau Proteins - cerebrospinal fluid, total tau, VaD, vascular dementia