CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in norway
2007
Details
- Autor(en) / Beteiligte
- Titel
- CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in norway
- Ist Teil von
- Sleep (New York, N.Y.), 2007-08, Vol.30 (8), p.969-973
- Ort / Verlag
- Rochester, MN: American Academy of Sleep Medicine
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- To evaluate the relationship between CSF hypocretin-1 levels and clinical profiles in narcolepsy and CNS hypersomnia in Norwegian patients. CSF hypocretin-1 was measured by a sensitive radioimmunoassay in 47 patients with narcolepsy with cataplexy, 7 with narcolepsy without cataplexy, 10 with idiopathic CNS hypersomnia, and a control group. Low hypocretin-1 values were found in 72% of the HLA DQB1*0602 positive patients with narcolepsy and cataplexy. Patients with low CSF hypocretin-1 levels reported more extensive muscular involvement during cataplectic attacks than patients with normal levels. Hypnagogic hallucinations and sleep paralysis occurred more frequently in patients with cataplexy than in the other patient groups, but with no correlation to hypocretin-1 levels. About three quarters of the HLA DQB1*0602 positive patients with narcolepsy and cataplexy had low CSF hypocretin-1 values, and appear to form a distinct clinical entity. Narcolepsy without cataplexy could not be distinguished from idiopathic CNS hypersomnia by clinical symptoms or biochemical findings.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0161-8105eISSN: 1550-9109DOI: 10.1093/sleep/30.8.969Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1978385
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Behavioral psychophysiology, Biological and medical sciences, Cataplexy - cerebrospinal fluid, Cataplexy - diagnosis, Cataplexy - genetics, Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes, Female, Fundamental and applied biological sciences. Psychology, Genetic Predisposition to Disease - genetics, Hallucinations - cerebrospinal fluid, Hallucinations - diagnosis, Hallucinations - genetics, HLA-DQ Antigens - genetics, HLA-DQ beta-Chains, Humans, Hypersomnolence, Idiopathic - cerebrospinal fluid, Hypersomnolence, Idiopathic - diagnosis, Hypersomnolence, Idiopathic - genetics, Intracellular Signaling Peptides and Proteins - cerebrospinal fluid, Intracellular Signaling Peptides and Proteins - genetics, Male, Medical sciences, Membrane Glycoproteins - genetics, Narcolepsy, Narcolepsy - cerebrospinal fluid, Narcolepsy - diagnosis, Narcolepsy - genetics, Nervous system (semeiology, syndromes), Neurology, Neuropeptides - cerebrospinal fluid, Neuropeptides - genetics, Orexins, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Radioimmunoassay, Reference Values, Risk Factors, Sleep Paralysis - cerebrospinal fluid, Sleep Paralysis - diagnosis, Sleep Paralysis - genetics