Details

Autor(en) / Beteiligte

• Gertz, Morie A.
• Lacy, Martha Q.
• Dispenzieri, Angela
• Greipp, Philip R.
• Litzow, Mark R.
• Henderson, Kimberly J.
• Van Wier, Scott A.
• Ahmann, Greg J.
• Fonseca, Rafael

Titel

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy

Ist Teil von

• Blood, 2005-10, Vol.106 (8), p.2837-2840

Ort / Verlag

Washington, DC: Elsevier Inc

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Fluorescence in situ hybridization (FISH) is more sensitive than conventional cytogenetics for recognizing chromosomal changes. Several FISH-detected abnormalities have been associated with inferior prognosis, including deletion of chromosomes 17 and 13 (Δ13) and t(4;14)(p16.3;q32). We analyzed the prognostic value of FISH testing in 238 patients who received high-dose therapy between January 1990 and September 2001. All patients had pretransplantation cytoplasmic immunoglobulin FISH done on cytospin slides from bone marrow aspirates for t(11;14), t(4;14), and -17(p13.1) (TP53). Time to progression and overall survival were significantly shorter for patients with t(4;14) and those with -17(p13.1) but were not affected by t(11;14). Overall survival was significantly shorter for patients with both t(4;14) and Δ13 abnormalities than for those with Δ13 alone (26.8 vs 18.8 months). In a multivariable analysis of the effect of Δ13 and t(4;14), the risk ratio for t(4;14) was greater than for Δ13 (2.6 vs 1.5). For high-dose therapy patients, -17(p13) and t(4;14) have clinical importance for estimating time to progression and overall survival. The presence of t(4;14) identifies a subset of patients whose time to progression is only 8.2 months. These patients receive minimal benefit from autologous stem cell transplantation and are candidates for novel therapeutic approaches. (Blood. 2005;106:2837-2840)