Heart (British Cardiac Society), 2006-07, Vol.92 (suppl 4), p.iv1-iv5
2006
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- Autor(en) / Beteiligte
- Titel
- Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium–calcium overload
- Ist Teil von
- Heart (British Cardiac Society), 2006-07, Vol.92 (suppl 4), p.iv1-iv5
- Ort / Verlag
- England: BMJ Publishing Group Ltd and British Cardiovascular Society
- Erscheinungsjahr
- 2006
- Quelle
- BMJ Journals Archiv - DFG Nationallizenzen
- Beschreibungen/Notizen
- Late sodium current in cardiac cells is very small compared with the fast component, but as it flows throughout the action potential it may make a substantial contribution to sodium loading during each cardiac cycle. Late sodium current may contribute to triggering arrhythmia in two ways: by causing repolarisation failure (early afterdepolarisations); and by triggering late afterdepolarisations attributable to calcium oscillations in sodium–calcium overload conditions. Reduction of late sodium current would therefore be expected to have therapeutic benefits, particularly in disease states such as ischaemia in which sodium–calcium overload is a major feature.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1355-6037eISSN: 1468-201XDOI: 10.1136/hrt.2005.078782Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1861316
- Format
- –
- Schlagworte
- [Na+]i, Arrhythmias, Cardiac - drug therapy, Arrhythmias, Cardiac - metabolism, Arrhythmias, Cardiac - physiopathology, Calcium, Calcium - metabolism, Calcium Channels - physiology, Cardiac arrhythmia, EAD, early afterdepolarisation, Heart failure, Humans, Hypoxia, IbNa, ICa, IKr, intracellular sodium concentration, IpNa, L-type inward calcium current, Laboratories, Myocardial Contraction - physiology, Myocardium - metabolism, Myocytes, Cardiac - metabolism, persistent sodium current, rapid delayed potassium current, Rodents, Sodium, Sodium - metabolism, sodium background current, Sodium Channels - physiology, Sodium-Calcium Exchanger - physiology, Studies, Tetrodotoxin - physiology