Details

Autor(en) / Beteiligte

• Chan, Annie On On
• Hui, Wai Mo
• Leung, Gigi
• Tong, Teresa
• Hung, Ivan F N
• Chan, Pierre
• Hsu, Axel
• But, David
• Wong, Benjamin C Y
• Lam, Shiu Kum
• Lam, Kwok Fai

Titel

Patients with functional constipation do not have increased prevalence of colorectal cancer precursors

Ist Teil von

• Gut, 2007-03, Vol.56 (3), p.451-452

Ort / Verlag

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Erscheinungsjahr

2007

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Colorectal cancer develops through the adenoma-carcinoma sequence. 5 Thus, we aimed to compare the prevalence of colorectal adenomas in patients with long-standing functional constipation to an age, sex and risk factors-matched control group in a prospective study. Table 1 Demographic data and prevalence of colonic lesions of the constipated and control groups Constipated group % (n = 214) Control group % (n = 215) p Value Demographic data Age (years), mean (SD) 61 (9) 61 (8) 0.93 Sex (female) 73.8 75.8 0.64 History of smoking 4.7 6 0.53 Diabetes 5.6 8.4 0.26 Family history of colorectal cancer 6.1 5.6 0.83 Prevalence of colonic lesion Endoscopic polyp 18.7 20.5 0.64 Adenoma 12.1 13 0.79 Hyperplastic polyp 2.8 4.7 0.31 Advanced colonic lesions 3.7 4.7 0.64 Colorectal cancer 0.47 0 0.32 It has been a laymans' concept that constipated patients may have higher risk of developing colorectal cancer owing to the accumulation of "toxic substances".