Molecular and cellular endocrinology, 2007-02, Vol.265-266, p.190-195
2007
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- Autor(en) / Beteiligte
- Titel
- Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development
- Ist Teil von
- Molecular and cellular endocrinology, 2007-02, Vol.265-266, p.190-195
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0303-7207eISSN: 1872-8057DOI: 10.1016/j.mce.2006.12.019Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1853274
- Format
- –
- Schlagworte
- Animals, Anterior pituitary, Growth, Homeodomain Proteins - genetics, Homeodomain Proteins - physiology, Hormone, Humans, LIM-Homeodomain Proteins, Mutation, Pituitary Gland - embryology, Pituitary Gland - physiology, Pituitary Hormones - genetics, Pituitary Hormones - metabolism, Transcription, Transcription Factors - genetics, Transcription Factors - physiology