Annals of the rheumatic diseases, 2003-03, Vol.62 (3), p.236-241
2003
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation
- Ist Teil von
- Annals of the rheumatic diseases, 2003-03, Vol.62 (3), p.236-241
- Ort / Verlag
- London: BMJ Publishing Group Ltd and European League Against Rheumatism
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Objectives: To determine whether myeloid related proteins (MRP8/MRP14), a complex of two S100 proteins related to neutrophil and monocyte activation, might be used as a marker for disease activity, and as an early indicator of relapse in juvenile idiopathic arthritis. Patients and methods: A group of 12 patients who underwent an autologous haematopoietic stem cell transplantation (ASCT) for refractory juvenile idiopathic arthritis (JIA) were studied. MRP8/MRP14 serum concentrations were determined by a sandwich enzyme linked immunosorbent assay (ELISA) as described. Improvement from baseline was described by a definition of improvement employing a core set of criteria as detailed previously by Giannini. Results: After ASCT, MRP8/MRP14 serum concentrations in JIA showed a positive correlation with the Child Health Assessment Questionnaire (CHAQ; r=0.80) and erythrocyte sedimentation rate (r=0.45), but not with the total leucocyte count (r=0.26). Mean MRP8/MRP14 serum concentrations dropped markedly in the first three months after ASCT (p=0.0039) and clinical parameters of disease activity such as CHAQ markedly improved (p=0.0039). During a transient relapse there was an increase in MRP8/MRP14. Conclusions: MRP8/MRP14 serum concentration can be used as a marker for disease activity in patients who receive an ASCT for refractory JIA. This indicates a role of macrophage activation in the pathogenesis of JIA. The occurrence of MAS in three patients in this study was not preceded by significant changes in MRP8/MRP14 concentration.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0003-4967eISSN: 1468-2060DOI: 10.1136/ard.62.3.236Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1754451
- Format
- –
- Schlagworte
- Adolescent, Age, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Arthritis, Arthritis, Juvenile - blood, Arthritis, Juvenile - physiopathology, Arthritis, Juvenile - therapy, ASCT, Autoimmune Diseases - blood, autologous stem cell transplantation, Biological and medical sciences, Blood Sedimentation, Bone marrow, stem cells transplantation. Graft versus host reaction, C reactive protein, Calgranulin A - blood, Calgranulin B - blood, CHAQ, Child, Child Health Assessment Questionnaire, Child, Preschool, creatine kinase, CRP, Disease, disease modifying antirheumatic drugs, DMARDs, Drug dosages, ELISA, Endothelium, enzyme linked immunosorbent assay, Enzyme-Linked Immunosorbent Assay - methods, erythrocyte sedimentation rate, ESR, Extended Report, Female, Fever, Growth hormones, Hematopoietic Stem Cell Transplantation, Humans, Infections, JIA, juvenile idiopathic arthritis, Leukocyte Count, macrophage activation syndrome, Male, MAS, Medical sciences, methotrexate, MRP, MTX, myeloid related protein, myeloid related proteins, Neutrophils, Phagocytes - physiology, Recurrence, SLE, Stem cells, Steroids, systemic lupus erythematosus, TNF, Transfusions. Complications. Transfusion reactions. Cell and gene therapy, Transplantation, Autologous, Transplants & implants, Tumor necrosis factor-TNF, tumour necrosis factor