Journal of neurology, neurosurgery and psychiatry, 2004-04, Vol.75 (4), p.643-644
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation
- Ist Teil von
- Journal of neurology, neurosurgery and psychiatry, 2004-04, Vol.75 (4), p.643-644
- Ort / Verlag
- London: BMJ Publishing Group Ltd
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To assess whether brain tissue loss occurs after profound and sustained suppression of magnetic resonance imaging (MRI) enhancement, we measured brain volume changes from 10 patients with rapidly evolving secondary progressive multiple sclerosis (MS) treated with autologous haematopoietic stem cell transplantation and followed up for 24 months. An average yearly decrease of brain volume of about 1.9% was observed despite only five enhancing lesions seen on triple dose follow up scans of two patients. This indicates that, in MS, progressive loss of tissue can occur independently of concomitant MRI-visible inflammation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3050eISSN: 1468-330XDOI: 10.1136/jnnp.2003.021865Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1738998
- Format
- –
- Schlagworte
- AHSCT, Atrophy, autologous haematopoietic stem cell transplantation, autologous stem cell transplantation, Biological and medical sciences, Brain - immunology, Brain - pathology, brain atrophy, Care and treatment, Complications and side effects, Contrast Media, diethylenetriamine penta-acetic acid, DTPA, enhancement, Follow-Up Studies, G-CSF, gadolinium, Gadolinium DTPA, granulocyte-colony stimulating factor, Hematopoietic Stem Cell Transplantation, Humans, Image Enhancement - methods, Image Processing, Computer-Assisted - methods, Inflammation, magnetic resonance imaging, Magnetic Resonance Imaging - methods, Medical sciences, MRI, Multiple sclerosis, Multiple Sclerosis, Chronic Progressive - immunology, Multiple Sclerosis, Chronic Progressive - therapy, NBV, Neurology, NMR, normalised brain volume, Nuclear magnetic resonance, Patients, PBVC, percentage normalised brain volume change, secondary progressive multiple sclerosis, Short Report, SPMS, Stem cells, Studies, Transplantation